Shuichi Sato, Ph.D., ATC

Assistant professor, Assistant Director, School of Kinesiology
Researcher at New Iberia Research Center (NIRC)
University of Louisiana at Lafayette

Office: Bourgeois Hall 129B, Email: s.sato@louisiana.edu

My research interest lies on the alternation of skeletal muscle size, physiology, and function due to aging, cancer and disuse and effects of exercise training in addition to pharmacological/nutritional reagents using in vitro and in vivo models.

My research career began in the Analytical Chemistry lab at Sophia University where I investigated the solvent-solute interaction between organic solvent and organometalic complex using mathematical models. Since I moved to the US, my interest shifted toward biology/physiology in humans ending up working on research at Integrative Muscle Biology lab of Dr. Carson in the Univ. of South Carolina. After getting a terminal degree at the institution, I had further research training at Dr. Kumar lab in the University of Louisville, School of Medicine.

I played football (not soccer) in high school and college in my country. So football is still my favorite sport and I like to watch football games in my spare time. But recently aging process teaches me how important physical activity/exercise is, mandating me to step on treadmill regularly. This experience further motivates me to study the role of exercise to fight against common chronic diseases.

Lab capability

Bourgeois Hall

Western blots
- Mini-PROTEAN Tetra System (Bio-Rad)
- Trans-Blot Turbo Transfer System (Bio-Rad)
- Wet/Tank blotting system (Bio-Rad)
- ChemiDoc Touch imaging system (Bio-Rad)
RNA isolation and qRT-PCR
- QIAcube (Qiagen)
- MiniAmp thermal cycler (Applied Biosystems)
- Mastercycler gradient thermal cycler(Eppendorf)
- Rotor-Gene Q (Qiagen)
Calorimetric assay and ELISA
- Multiskan Sky (Thermofisher)
- ELx808 (BioTek)
- Qubit 3.0 (Invitrogen)
- Evolution 60S (Thermofisher)
- Biophotometer (Eppendorf)
Agarose gel electrophoresis
- Mini-Sub Cell GT gel electrophoresis system (Bio-Rad)
- E-Gel Power Snap electrophoresis system and camera (Thermofisher)
- BA310 Light microscope with camera (Motic)

To be continued

New Iberia Research Center (NIRC)

Mouse housing/exercise equipment
- Mouse microisolator caging system (Ancare)
- Mouse treadmill (Columbus Instruments)
- In-vivo muscle stimulation system (Aurora Scientific)
RNA isolation and qRT-PCR
- Thermal cycler (Bio-Rad and Applied Biosystems)
- StepOnePlus (Applied Biosystems)
Flow cytometry and cell sorting
- FacsCalibur Flow Cytometer (Becton Dickenson)

To be continued

Education & Training

2015 - Post-Doc, Cell Biology, Univ. of Louisville School of Medicine

2012 - Ph.D., Applied Physiology, Univ. of South Carolina

2005 - MS, Exercise Science, Univ. of Southern Mississippi

2003 - BS, Athletic Training, Univ. of Southern Mississippi

1996 - MS, Chemistry, Sophia University

1994 - BS, Chemistry, Sophia University

CV as of April 2019



Louisiana BoRSF Research Competitiveness Subprogram (PI: Sato, 2017-2020)
Title:The effect of Yes-associated protein YAP during the development of cancer cachexia


Yamada Research Fund (PI: Sato, 2016-2017)
Title: The effect of royal jelly on satellite cell activation in aged nonhuman primate in vitro

Research Interests

  • Skeletal muscle
  • Satellite Cells
  • Hippo signaling
  • CRISPR-Cas9
  • ER Stress/Unfolded Protein Response
While molecular/cell biology techniques has been used for my studies, I would like to integrate analytical chemistry approach into my future research agenda. So I am willing to welcome students/scholars who have different experiences/backgrounds to my lab.

Age-related decrease in muscle satellite cells is accompanied with diminished expression of early growth response 3 in mice

Ogura Y, Sato S, Kurosaka M, Kotani T, Fujiya H, Funabashi T.

Mol Biol Rep. 2020 Feb;47(2):977-986. doi: 10.1007/s11033-019-05189-5.

Keywords: Myogenesis, FACS, Stem cells, Sarcopenia, Regeneration

High-Frequency Stimulation on Skeletal Muscle Maintenance in Female Cachectic Mice.

Sato S, Gao S, Puppa MJ, Kostek MC, Wilson LB, Carson JA.

Med Sci Sports Exerc. 2019 Sep;51(9):1828-1837. doi: 10.1249/MSS.0000000000001991.

Keywords: Cachexia, mTOR, protein synthesis, resistance exercise

TAK1 regulates skeletal muscle mass and mitochondrial function.

Hindi SM, Sato S, Xiong G, Bohnert KR, Gibb AA, Gallot YS, McMillan JD, Hill BG, Uchida S, Kumar A.

JCI Insight. 2018 Feb 8;3(3). pii: 98441.

Keywords: Metabolism, Mouse models, Muscle Biology, Skeletal muscle

Inhibition of ER stress and unfolding protein response pathways causes skeletal muscle wasting during cancer cachexia

Bohnert KR, Gallot YS, Sato S, Xiong G, Hindi SM, and Kumar A.

FASEB J. 2016 Sep;30(9):3053-68. doi: 10.1096/fj.201600250RR.

Keywords: Cancer cachexia, ER stress, skeletal muscle, AKT, Unfolding protein response

Eccentric Contraction-Induced Myofiber Growth in Tumor-Bearing Mice

Hardee JP, Mangum J, Gao S, Sato S, Hetzler KL, Puppa MH, Fix D, and Carson JA.

J Appl Physiol (1985). 2016 Jan 1;120(1):29-37. doi: 10.1152/japplphysiol.00416.2015.

Keywords: cancer cachexia, eccentric contractions, high-frequency electrical stimulation, muscle inflammation, myofiber growth

TAK1 modulates satellite stem cell homeostasis and skeletal muscle repair

Ogura Y, Hindi SM, Sato S, Xiong G, Akira S, and Kumar A.

Nat Commun. 2015 Dec 9;6:10123. doi: 10.1038/ncomms10123

Keywords: transforming growth factor-b-activated kinase 1, TAK1, muscle regeneration, satellite cell

Sex differences in the relationship of IL-6 signalling to cancer cachexia progression

Hetzler KL, Hardee JP, Puppa MJ, Narsale AA, Sato S, Davis JM, and Carson JA.

Biochim Biophys Acta. 2015 May;1852(5):816-25. doi: 10.1016/j.bbadis.2014.12.015.

Keywords: Apc(Min/+), IL-6r, SOCS3, STAT3, Skeletal muscle.

Elevated levels of TWEAK in skeletal muscle promote visceral obesity, insulin resistance, and metabolic dysfunction

Sato S, Ogura Y, Tajrishi MM, and Kumar A.

FASEB J. 2015 Mar;29(3):988-1002. doi: 10.1096/fj.14-260703.

Keywords: AMPK, Fn14, GLUT4, PGC-1α, type 2 diabetes

Therapeutic potential of matrix metalloproteinases in Duchenne muscular dystrophy

Ogura Y, Tajrishi MM, Sato S, Hindi SM, Kumar A.

Front Cell Dev Biol. 2014 Apr 1;2:11. doi: 10.3389/fcell.2014.00011. eCollection 2014.

Keywords: NF-κB, TIMPs, fibrosis, inflammation, macrophages, matrix metalloproteinases, skeletal muscle

The TWEAK-Fn14 dyad is involved in age-associated pathological changes in skeletal muscle

Tajrishi MM, Sato S (equal contribution), Shin J, Zheng TS, Burkly LC, Kumar A.

Biochem Biophys Res Commun. 2014 Apr 18;446(4):1219-24. doi: 10.1016/j.bbrc.2014.03.084.

Keywords: Autophagy, Cytokines, NF-κB, Sarcopenia, Ubiquitin–proteasome system

TWEAK/Fn14 Signaling Axis Mediates Skeletal Muscle Atrophy and Metabolic Dysfunction

Sato S, Ogura Y, and Kumar A.

Front Immunol. 2014 Jan 27;5:18. doi: 10.3389/fimmu.2014.00018. eCollection 2014.

Keywords: Fn14, TWEAK, atrophy, oxidative phosphorylation, skeletal muscle

Distinct roles of TRAF6 at early and late stages of muscle pathology in the mdx model of Duchenne muscular dystrophy

Hindi SM, Sato S, Choi Y, and Kumar A

Hum Mol Genet. 2014 Mar 15;23(6):1492-505. doi: 10.1093/hmg/ddt536.

Keywords: TRAF6, Duchenne muscular dystrophy, nf-kb

TWEAK promotes exercise intolerance by decreasing skeletal muscle oxidative phosphorylation capacity

Sato S, Ogura Y, Mishra V, Shin J, Bhatnagar S, Hill BG, and Kumar A

Skelet Muscle. 2013 Jul 8;3(1):18. doi: 10.1186/2044-5040-3-18.

Keywords: Skeletal muscle, exercise tolerance, TWEAK, Fn14, PGC-1α, PPARδ

Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK

White JP, Puppa MJ, Gao S, Sato S, Welle SL, and Carson JA

Am J Physiol Endocrinol Metab. 2013 May 15;304(10):E1042-52. doi: 10.1152/ajpendo.00410.2012

Keywords: AMPK, IGF-I, IL-6, STAT, cachexia, colorectal cancer, exercise, inflammation, mTOR, muscle, protein synthesis, wasting

Development of an UPLC mass spectrometry method for measurement of myofibrillar protein synthesis: application to analysis of murine muscles during cancer cachexia.

Lima M, Sato S, Enos RT, Baynes JW, and Carson JA

J Appl Physiol (1985). 2013 Mar 15;114(6):824-8. doi: 10.1152/japplphysiol.01141.2012.

Keywords: cachexia, myofibrillar protein synthesis, soleus, plantaris, ultra-performance liquid chromatography mass spectrometry

Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle

White JP, Gao S, Puppa MJ, Sato S, Welle SL, and Carson JA.

Mol Cell Endocrinol. 2013 Jan 30;365(2):174-86. doi: 10.1016/j.mce.2012.10.019.

Keywords: Muscle, Testosterone, FOXO3a, Akt, mTOR, AMPK

IL-6 regulation of muscle mitochondrial biogenesis and fission/fusion dynamics during the progression of cancer cachexia

White JP, Sato S, Puppa MJ, Baynes JW, Kostek, MC, Matesic LE and Carson JA.

Skeletal Muscle. 2012 Jul 6;2:14. doi: 10.1186/2044-5040-2-14.

Keywords: FIS1, PGC-1α, Exercise, IL-6r, MFN1, Cachexia, Mitochondria, Muscle, Autophagy

The Effect of Exercise on IL-6-induced Cachexia in the ApcMin/+ mouse

Puppa MJ, White JP, Velasquez KT, Baltgalvis KA, Sato S, Baynes JW, and Carson JA.

J Cachexia Sarcopenia Muscle. 2012 Jun;3(2):117-37. doi: 10.1007/s13539-011-0047-1.

Keywords: Inflammation, Colorectal cancer, Insulin resistance, Oxidative capacity

Gut barrier dysfunction in the ApcMin/+ mouse model of colon cancer cachexia

Puppa MJ, White JP, Sato S, Cairns M, Baynes JW, and Carson JA.

Biochimica et Biophysica Acta – Molecular Basis of Disease. Dec;1812(12):1601-6.

Keywords: Cachexia, Colorectal cancer, Endotoxin, Gut barrier dysfunction, Gut permeability, Inflammation

The regulation of skeletal muscle protein turnover during the progression of cancer cachexia in the ApcMin/+ mouse

White JP, Baynes JW, Welle SL, Kostek MC, Matesic LE, Sato S, and Carson JA.

PLoS ONE 6(9): e24650. doi:10.1371/journal.pone.0024650

Keywords: cachexia, protein synthesis, protein degradation, mTOR, FOXO, Ubiquitin–proteasome system

Skeletal muscle mass recovery from atrophy in IL-6 knockout mice

Washington TA, White JP, Davis JM, Wilson LB, Lowe LL, Sato S, and Carson JA.

Acta Physiol (Oxf). Acta Physiol (Oxf). 2011 Aug;202(4):657-69.

Keywords: inflammation, myogenesis, muscle regeneration, hypertrophy, IGF-1, mTOR, Stat3

Muscle oxidative capacity during IL-6 dependent cancer cachexia

White JP, Baltgalvis KA, Puppa MJ, Sato S, Baynes JW, and Carson JA.

Am J Physiol Regul Integr Comp Physiol; 2011 Feb;300(2):R201-11.

Keywords: mitochondria, wasting, mitofusin-2 protein, fission 1 protein

The effect of nandrolone decanoate administration on recovery from bupivacaine-induced muscle injury

White JP, Baltgalvis KA, Sato S, Wilson LB, and Carson JA

J Appl Physiol. 2009 Nov;107(5):1420-30.

Keywords: muscle regeneration, anabolic steroids, myotoxin

Overload-induced skeletal muscle extracellular matrix remodelling and myofibre growth in mice lacking IL-6.

White JP, Reecy JM, Washington TA, Sato S, Le ME, Davis JM, Wilson LB, and Carson JA

Acta Physiol (Oxf). 2009 Dec;197(4):321-32.



Looking for lab members

Sato lab always looks for graduate/undergraduate students who are interested in skeletal muscle biology research. Please email Sato for details.


A student seeking for a Master's degree is expected to enroll in Masters in Kinesiology. (FYI. No GRE score is required for the admission of this program).

If you are interested in Ph.D., admission to Doctorate in Biology Program is required while working in my lab.


Research Presentation

Our graduate student Richard provided his poster presentation in Cancer Cachexia Conference in September 2020. The title of his presentation was "Increased sensitivity to systemic inflammation leads to elevated MMP-9 expression in mouse cachectic muscle".

Research Presentation

Our graduate student Richard provided his poster presentation in Experimental Biology in April 2020. The title of his presentation was "YAP Involves in Reduced Anabolic Response to Functional Overload in Lewis Lung Carcinoma-bearing Mice".

Guess who are there in the official SEACSM tweet?

Research Presentation

Our graduate student Richard provided his poster presentation in Master's student poster competition at Southeast ACSM annual meeting in Jacksonville, FL in February 2020. The title of his presentation was "Reduced unfolded protein response is associated with anabolic resistance following mechanical overload in ApcMin/+ mice".

Research Presentation

Our undergraduate student Emily provided her presentation in the thematic poster session at Southeast ACSM annual meeting in Jacksonville, FL in February 2020. The title of her presentation was "Compromised anabolic response to mechanical overload leads to decreased muscle hypertrophy in tumor-implanted mice".

Research Presentation

Our undergraduate student Emily provided her poster presentation at LaCOEUR - Undergraduate Research Conference in Lafayette, LA in November 2019. The title of her presentation was "Impaired anabolic response leads to decreased muscle protein synthesis in colon cancer mice".


Our manuscript titled "Age-related decrease in muscle satellite cells is accompanied with diminished expression of early growth response 3 in mice" was accepted by Molecular Biology Report on 11/7/2019 and available online (here!).

Research Presentation

Our presentation led by Richard, a graduate student in Sato lab, was selected as a finalist for the student Master’s awards poster session for the SEACSM annual meeting in Jacksonville, FL in February 2020.

Research Presentation

Our undergraduate student Emily provided her poster presentation at Student Research Symposium at the UL Lafayette in May 2019. The title of her presentation was "Reduced mTOR response after 7-day mechanical overload in cachetic mice".

Research Presentation

Sato provided a poster presentation at Experimental Biology in Orlando, FL in April 2019. The title of presentation was "The Effect of Royal Jelly on Satellite Cell Activation in Aged Monkey Muscle Cells". The abstract can be found here on FASEB journal.


Our manuscript titled "High-frequency stimulation on skeletal muscle maintenance in female cachectic mice" was accepted by MSSE on 3/15/2019 and available online on 3/30/2019. See the following link (here!) for details.

Research Presentation

Our undergraduate student Kayla presented her poster titled "Impaired Compensatory Muscle Hypertrophy Following 7 days of Functional Overload in ApcMin/+ Mice" in 2019 Southeast ACSM annual meeting in February 2019. She was selected as a finalist for the student undergraduate awards poster session.

Research Presentation

Sato presented his poster at 11th International Conference on Cachexia, Sarcopenia, and Muscle wasting in Maastricht, Netherland in December 2018. The title of his poster was Potential involvement of Yes-Associated Protein in anabolic resistance during mechanical loading in cachectic mice.


Sato has been appointed to the Joan D. and Alexander S. Haig/BORSF Professorship in Education (2018-2021)

Research Presentation

Our undergraduate students Emily and Taylor presented their poster at Student Research Symposium at the UL Lafayette in April 2018. The title of their presentation was "Genotyping ApcMin/+ Mice with a standard PCR"


A new manuscript has been published in JCI insight on 2/8/2018. https://insight.jci.org/articles/view/98441


Sato received Travel Grants for Emerging Faculty (TGEF) from Louisiana Experimental Program to Stimulate Competitive Research (EPSCoR) in September 2017.

Research Presentation

Undergraduate students Janesha and Ben presented their poster at Experimental Biology 2017 in Chicago. The title of the presentation was "The Role of Hippo Signaling Pathway on Muscle Wasting in ApcMin/+ Mice: A Pilot Study".

Get in Touch!

Last update: Jan 13, 2021